A short Q&A asking one of our cohort about his experiences of doing a PhD
Haneesh, a PhD student with the Florey Institute, has taken the time to talk to us about his research project and how he has found doing a PhD in general!
What is the main focus of your research?
My main focus is developing novel chemical probes to image penicillin binding proteins (PBP’s) with the aim to elucidate their mechanisms in cell wall biosynthesis and role in antibiotic resistance. PBP’s are of high interest as we do not know how they have developed resistance to traditional β-lactam antibiotics such as penicillin, leading to highly resistant bacterial strains such as MRSA.
What implications does this have for your area?
Discerning the precise dynamics of PBP’s are of huge importance to gain insight into the major defence component of bacteria, the cell wall. Further understanding the biosynthesis of the cell wall will allow the effective design of future antibiotic drugs.
How have you found doing a PhD challenging/rewarding?
I enjoy learning new concepts on a regular basis and applying these to solve problems that I have in my work. Of course, not everything works first time (or second, or third!!) but that is to be expected in scientific research – overcoming these problems is what makes it so fun! Knowing that I am working on a critical part of healthcare is a big motivation for me and something which drives me on a daily basis. Being of a pure chemistry background, the biggest challenge for me has been to grasp the biology parts of my project. However, this has also been one of the most enjoyable aspects
as it’s given me the opportunity to be part of a wider multidisciplinary field which is becoming ever more important in tackling major healthcare challenges.
What would your top tip for prospective PhD students?
My top tip would be to have a healthy work-life balance during your PhD. A PhD is highly rewarding but also a lot of hard work so it’s important to keep your mind fresh. Do activities you enjoy outside of work on a regular basis, treat yourself, and take regular breaks during the year
(we all love a vacation! :) ).
