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The Florey Institute's
6th Annual Postgraduate Symposium The Hidden Army:
Integrated approaches to fight infection 28th June 2019, Firth Hall, University of Sheffield Find out more here
Follow on twitter at: #Florey 2019 |
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The Florey Insitute launches the
Hosted by the University of Sheffield and supported by the NHS, this MSc programme has been designed to train the healthcare workers, policy makers and scientists of tomorrow. For more inforamtion about this course please
CLICK HERE. |
The Florey Institute Research Forum (FIRF) - Meeting Dates 2019
Our research forum includes talks from our student cohort and guest speakers.
Our research forum includes talks from our student cohort and guest speakers.
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21/01/2019
06/03/2019 15/04/2019 29/05/2019 08/07/2019 |
(Monday)
(Wednesday) (Monday) (Wednesday) (Monday) |
14:00-15:00
14:00-15:00 14:00-15:00 14:00-15:00 14:00-15:00 |
LT01- Arts Tower
G2 - Firth Court LT01- Arts Tower LT03 - Med School G2 - Firth Court |
Florey Institute Seminar Series (2018-19)
We are delighted to welcome Dr Siobhán O’Brien from the University of Liverpool who will give our next Florey Seminar.
Dr O'Brien's lab studies, cystic fibrosis which is a fatal genetic disorder where patients are predisposed to lifelong lung infections. The most common cause of mortality in cystic fibrosis patients is chronic infection with Pseudomonas aeruginosa, an antibiotic-resistant, virulent pathogen that is virtually impossible to eradicate once established. There is currently no cure for cystic fibrosis, and it remains the most common fatal genetic disease in Europe.
We are delighted to welcome Dr Siobhán O’Brien from the University of Liverpool who will give our next Florey Seminar.
Dr O'Brien's lab studies, cystic fibrosis which is a fatal genetic disorder where patients are predisposed to lifelong lung infections. The most common cause of mortality in cystic fibrosis patients is chronic infection with Pseudomonas aeruginosa, an antibiotic-resistant, virulent pathogen that is virtually impossible to eradicate once established. There is currently no cure for cystic fibrosis, and it remains the most common fatal genetic disease in Europe.
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Speaker
Title Date Time Venue |
Dr Siobhán O’Brien
Friend or foe: The role of “context” in cystic fibrosis lung infections Thursday 30th May 2019 1:00 pm F2, Firth Court |
Abstract
Cystic fibrosis is a fatal genetic disorder, where patients are predisposed to lifelong lung infections. The most common cause of mortality in cystic fibrosis patients is chronic infection with Pseudomonas aeruginosa, an antibiotic-resistant, virulent pathogen that is virtually impossible to eradicate once established. There is currently no cure for cystic fibrosis, and it remains the most common fatal genetic disease in Europe.
Our understanding of cystic fibrosis has changed dramatically from considering Pseudomonas aeruginosa infections as simple, non-interacting cells within a sterile lung, towards our current understanding that infections are dynamic, variable, embedded within multi-species environments, and rapidly evolving. This raises questions such as:
Cystic fibrosis is a fatal genetic disorder, where patients are predisposed to lifelong lung infections. The most common cause of mortality in cystic fibrosis patients is chronic infection with Pseudomonas aeruginosa, an antibiotic-resistant, virulent pathogen that is virtually impossible to eradicate once established. There is currently no cure for cystic fibrosis, and it remains the most common fatal genetic disease in Europe.
Our understanding of cystic fibrosis has changed dramatically from considering Pseudomonas aeruginosa infections as simple, non-interacting cells within a sterile lung, towards our current understanding that infections are dynamic, variable, embedded within multi-species environments, and rapidly evolving. This raises questions such as:
- What makes an infecting microbe turn from “good” to “bad”?
- What constitutes a “healthy” lung microbiome in cystic fibrosis?
- How variable are Pseudomonas aeruginosa infections in terms of virulence?
- Can we manipulate the microbiome to resist invasion by harmful microbes?
Dr Tregoning tweets under the handle: @Siderophile