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Day 7 - Living without oxygen

14/3/2019

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Natalia Hajdamowicz and Rebecca Hull work alongside Prof. Alison Condliffe investigating the impact of low-oxygen conditions on interactions between the human immune system and the infectious bacterium Staphylococcus aureus (also called MRSA).
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Staphylococcus aureus has the propensity to develop anti-microbial resistance, causing a variety of infections which are becoming increasingly challenging to treat. In the Condliffe lab we use the SCI-tive Ruskinn hypoxic workstation (see photo below) to incubate cells in low-oxygen conditions equivalent to those encountered in our blood stream.

During infections S. aureus have evolved to circumvent our immune systems and this seems especially true in low-oxygen environments. Consequently, a deeper understanding of how our immune cells interface with the bacteria in real infection environments is essential.

In the Condliffe lab:

Natalia, a 3rd year Florey Institute PhD student, is looking at the mechanisms behind this host-pathogen interaction.

Rebecca, a 1st year MRF PhD student (
@MedResFdn), is looking at the evolutionary adaptations of these bacteria within this immune environment.

Exploring molecular mechanisms underlying host-pathogen interactions may lead to the development of successful treatment of intracellular infections by targeting host cell functions supporting bacterial growth or augmenting bactericidal functions.
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Natalia (left) and Rebecca (right) growing cells in the SCI-tive Ruskinn hypoxic workstation, a low-oxygen cabinet that mimics oxygen conditions found in the human blood stream.
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