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Day 10 - Using state of the art technology to image bacteria

18/3/2018

2 Comments

 
Using state of the art technology to image bacteria

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Using cryo-electron microscopy in the Bergeron laboratory

My group use biophysical techniques to decipher the molecular details of large protein complexes involved in bacterial pathogenesis and antibiotic resistance. In particular, we are exploiting high-resolution cryo-electron microscopy (cryo-EM) for studying potential new antibiotics targets. In the past three years, cryo-EM has revolutionized our capacity to look at biological molecules at the level of individual atoms.  
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Specifically, we are studying the bacterial flagellum, a long rotating filament that acts as a propeller, allowing them to move and adhere on the surface of target cells. For pathogenic bacteria (such as E. coli, Salmonella and Yersinia), flagella can aid the spread of disease, and helps them attach to medical devices such as catheters. As a consequence, understanding the bacterial flagellum at the molecular level could have numerous medical implications, and disrupting its rotation and adherence properties could significantly reduce infection in a clinical setting. Because of its size and complexity, characterizing the flagellum at the molecular level was previously impossible. But with the recent advances of cryo-EM, we can now study this complex with unprecedented detail.

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​We are currently investigating the atomic details of the flagellum tip, to try and understand how it adheres onto human cells. We are also trying to decipher the architecture of the “basal body”, the region of the flagellum that is anchored at the bacterial surface and that acts as an anchoring point for its assembly. Ultimately, our research could be exploited to generate new antibiotics that block the formation or function of the flagellum.

Read more about Julien's research at: 
www.bergeronlab.com
Follow the official hashtag on twitter: #BSW18 
2 Comments
college-paper.org reviews link
2/7/2018 07:21:27 am

Such technology could be revolutionary for avoiding from any type of bacteria which is not good for the human body. We are sure to give the tribute to the person that has been able to introduce this tech.

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this site link
25/11/2018 08:27:14 am

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