PublicationsThe Florey Team regularly publish in a number of high profile research journals. Recent examples are given on this page with links to associated press releases, articles and blogs discussing the work where possible.
2019
Lindsey BB, Jagne YJ, Armitage EP, Singanayagam A, Sallah HJ, Drammeh S, Senghore E, Mohammed NI, Jeffries D, Höschler K, Tregoning JS, Meijer A, Clarke E, Dong T, Barclay W, Kampmann B, de Silva TI. Effect of a Russian-backbone live-attenuated influenza vaccine with an updated pandemic H1N1 strain on shedding and immunogenicity among children in The Gambia: an open-label, observational, phase 4 study. Lancet Respir Med. 2019. Jun 21. pii: S2213-2600(19)30086-4.
Lancet Podcast: 'Live-attenuated influenza vaccines in children' by Thushan de Silva Sharla M. McTavish, Sarah J. Snow, Ellie C. Cook, Bruno Pichon, Sarah Coleman, Geoffrey W. Coombs, Stanley Pang, Cesar A. Arias, Lorena Díaz, Emma Boldock, Steve Davies, Mangala Udukala, Angela Marie Kearns, Sisira Siribaddana and Thushan I. de Silva Genomic and Epidemiological Evidence of a Dominant Panton-Valentine Leucocidin-Positive Methicillin Resistant Staphylococcus aureus Lineage in Sri Lanka and Presence Among Isolates From the United Kingdom and Australia. Front. Cell. Infect. Microbiol. 2019. Apr 26;9:123 Flores-Kim J, Dobihal GS, Fenton AK, Rudner DZ, Bernhardt TG. A switch in surface polymer biogenesis triggers growth-phase-dependent and antibiotic-induced bacteriolysis. Elife. 2019. Reglinski M, Sriskandan S, Turner CE. Identification of two new core chromosome-encoded superantigens in Streptococcus pyogenes; speQ and speR. J Infect. 2019. pii: S0163-4453(19)30054-4
Brockhurst MA, Harrison F, Veening JW, Harrison E, Blackwell G, Iqbal Z, Maclean C. Assessing evolutionary risks of resistance for new antimicrobial therapies. Nature Ecology & Evolution. 2019.
Yang D, Ho YX, Cowell LM, Jilani I, Foster SJ and Prince LR. A Genome-Wide Screen Identifies Factors Involved in S. aureus-Induced Human Neutrophil Cell Death and Pathogenesis. Front. Immunol. 2019 10:45. DOI: 10.3389/fimmu.2019.00045
Preston JA, Bewley MA, Marriott HM, Houghton AM, Mohasin M, Jubrail j, Morris L, Stephenson YL, Cross S, Greaves DR, Craig RW, van Rooijen N, Bingle CD, Read RC, Mitchell TJ, Whyte MKB, Shapiro SD, Dockrell DH. Alveolar Macrophage ApoptosisAssociated Bacterial Killing Helps Prevent Murine Pneumonia. Am J Respir Crit Care Med. 2019 DOI: 10.1164/rccm.201804-0646OC 2018 Boldock E, Surewaard BGJ, Shamarina D, Na M, Fei Y, Ali A, Williams A, Pollitt EJG, Szkuta P, Morris P, Prajsnar TK, McCoy KD, Jin T, Dockrell DH, van Strijp JAG, Kubes P, Renshaw SA, Foster SJ. Human skin commensals augment Staphylococcus aureus pathogenesis. Nat Microbiol. 2018 Aug;3(8):881-890.
Patel DS, Khan IJ, Zayed MG, Partridge D, Rennie IG, Mudhar HS, Sheard R. Full diagnostic vitrectomy with posterior vitreous detachment induction for the diagnosis of virits due to uncertain Etiology. Retina. 2018 Jul 10.
Collini PJ, Bewley MA, Mohasin M, Marriott HM, Miller RF, Geretti AM, Beloukas A, Papadimitropoulos A, Read RC, Noursadeghi M, Dockrell DH. HIV gp120 in the Lungs of Antiretroviral Therapy-treated Individuals Impairs Alveolar Macrophage Responses to Pneumococci. Am J Respir Crit Care Med. 2018 Jun 15;197(12):1604-1615.
Edwards RJ, Pyzio M, Gierula M, Turner CE, Abdul-Salam VB, Sriskandan S.
Proteomic analysis at the sites of clinical infection with invasive Streptococcus
pyogenes. Sci Rep. 2018 Apr 13;8(1):5950.
Turner RD, Mesnage S, Hobbs JK, Foster SJ. Molecular imaging of glycan chains couples cell-wall polysaccharide architecture to bacterial cell morphology. Nat Commun. 2018 Mar 28;9(1):1263.
Darton TC, Tuyen HT, The HC, Newton PN, Dance DAB, Phetsouvanh R, Davong V, Campbell JI, Hoang NVM, Thwaites GE, Parry CM, Thanh DP, Baker S. Azithromycin Resistance in Shigella spp. in Southeast Asia. Antimicrob Agents Chemother. 2018 Mar 27;62(4).
Fenton AK, Manuse S, Flores-Kim J, Garcia PS, Mercy C, Grangeasse C, Bernhardt TG, Rudner DZ. Phosphorylation-dependent activation of the cell wall synthase PBP2a in Streptococcus pneumoniae by MacP. Proc Natl Acad Sci U S A. 2018 Mar 13;115(11):2812-2817.
Remmington A, Turner CE. The DNases of pathogenic Lancefield streptococci. Microbiology. 2018 Mar;164(3):242-250.
van Leeuwen LM, Evans RJ, Jim KK, Verboom T, Fang X, Bojarczuk A, Malicki J, Johnston SA, van der Sar AM. A transgenic zebrafish model for the in vivo study of the blood and choroid plexus brain barriers using claudin 5. Biol Open. 2018 Feb 2;7(2).
Lund VA, Wacnik K, Turner RD, Cotterell BE, Walther CG, Fenn SJ, Grein F, Wollman AJ, Leake MC, Olivier N, Cadby A, Mesnage S, Jones S, Foster SJ. Molecular coordination of Staphylococcus aureus cell division. E.life. 2018 Feb 21;7. pii: e32057.
Irving SE, Corrigan RM. Triggering the stringent response: signals responsible
for activating (p)ppGpp synthesis in bacteria. Microbiology. 2018
Mar;164(3):268-276.
Thwaites GE, Scarborough M, Szubert A, Nsutebu E, Tilley R, Greig J, Wyllie SA, Wilson P, Auckland C, Cairns J, Ward D, Lal P, Guleri A, Jenkins N, Sutton J, Wiselka M, Armando GR, Graham C, Chadwick PR, Barlow G, Gordon NC, Young B, Meisner S, McWhinney P, Price DA, Harvey D, Nayar D, Jeyaratnam D, Planche T, Minton J, Hudson F, Hopkins S, Williams J, Török ME, Llewelyn MJ, Edgeworth JD, Walker AS; United Kingdom Clinical Infection Research Group (UKCIRG). Adjudicative Rifampicin for Staphylococcus aureus bacteraemia (ARREST): a multicentre, randomised, double-blind, placebo-controlled trial. Lancet. 2017 Feb 17;391(10121):668-678.
Samuelson C, Kaur H, Kritsotakis EI, Goode SD, Nield A, Partridge D. A daily topical decontamination regimen reduces catheter-related bloodstream infections in haematology patients. J Infect. 2018 Feb;76(2):132-139. 2017 Connolly J, Boldock E, Prince LR, Renshaw SA, Whyte MK, Foster SJ. Identification of Staphylococcus aureus Factors Required for Pathogenicity and Growth in Human Blood. Infect Immun. 2017 Oct 18;85(11).
Shamarina D, Stoyantcheva I, Mason CE, Bibby K, Elhaik E. Communicating the promise, risks, and ethics of large-scale, open space microbiome and metagenome research. Microbiome. 2017 Oct 4;5(1):132
Bewley MA, Preston JA, Mohasin M, Marriott HM, Budd RC, Swales J, Collini P, Greaves DR, Craig RW, Brightling CE, Donnelly LE, Barnes PJ, Singh D, Shapiro SD, Whyte MKB, Dockrell DH. Impaired Mitochondrial Microbicidal Responses in Chronic Obstructive Pulmonary Disease Macrophages. Am J Respir Crit Care Med. 2017 Oct 1;196(7):845-855.
Kirk JA, Gebhart D, Buckley AM, Lok S, Scholl D, Douce GR, Govoni GR, Fagan RP. New class of precision antimicrobials redefines role of Clostridium difficile S-layer in virulence and viability. Sci Transl Med. 2017 Sep 6;9(406)
Hall JPJ, Williams D, Paterson S, Harrison E, Brockhurst MA. Positive selection inhibits gene mobilisation and transfer in soil bacterial communities. Nat Ecol Evol. 2017 Sep;1(9):1348-1353.
Bottery MJ, Wood AJ, Brockhurst MA. Adaptive modulation of antibiotic resistance through intragenomic coevolution. Nat Ecol Evol. 2017 Sep;1(9):1364-1369.
Turner CE, Bedford L, Brown NM, Judge K, Török ME, Parkhill J, Peacock SJ. Community outbreaks of group A Streptococcus revealed by genome sequencing. Sci Rep. 2017 Aug 17;7(1):8554.
Gilbert AS, Seoane PI, Sephton-Clark P, Bojarczuk A, Hotham R, Giurisato E, Sarhan AR, Hillen A, Velde GV, Gray NS, Alessi DR, Cunningham DL, Tournier C, Johnston SA, May RC. Vomocytosis of live pathogens from macrophages is regulated by the atypical MAP kinase ERK5. Sci Adv. 2017 Aug 16;3(8):e1700898.
Salamaga B, Prajsnar TK, Jareño-Martinez A, Willemse J, Bewley MA, Chau F, Belkacem BT, Meijer AH, Dockrell DH, Renshaw SA, Mesnage S. Bacterial size matters: Multiple mechanisms controlling septum cleavage and diplococcus formation are critical for the virulence of the opportunistic pathogen Enterococcus faecalis. PLoS Pathog. 2017 Jul 24;13(7):e1006526.
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