Past events
|
For Better and For Worse: Bacterial Cell Wall Interactions with the Host As part of the Florey launch celebrations, an MRC funded workshop was held at the University of Sheffield on Monday 18th September to examine the complex interplay between the bacterial cell wall (in particular the structural polymer peptidoglycan) and our immune systems. |
|
Fun, family activities in the Winter Garden
On 16-17 September 2017, our scientists held a public engagement event in the Winter Garden, under the
giant inflatable E.coli, as part of the Florey launch celebrations.
Activities included
On 16-17 September 2017, our scientists held a public engagement event in the Winter Garden, under the
giant inflatable E.coli, as part of the Florey launch celebrations.
Activities included
- A chance to see how many bacteria are growing on your hands
- Visualise bacteria under a microscope and growing on agar plates
- Build your own microbe
- Learning proper handwashing technique to prevent the spread of germs and disease!
Florey / SHAMROK seminar series: 03 July 17
On Monday 03 July 2017, Dr Dominika Gruszka (The Francis Crick Institute) gave a talk entitled 'Intrinsic disorder drives the assembly of SasG, an elongated and mechanically strong Staphylococcus aureus biofilm-promoting protein'.
On Monday 03 July 2017, Dr Dominika Gruszka (The Francis Crick Institute) gave a talk entitled 'Intrinsic disorder drives the assembly of SasG, an elongated and mechanically strong Staphylococcus aureus biofilm-promoting protein'.
MRC Festival of Medical Research: Free Activities and Demos
This free public engagement event was held in the Winter Gardens, Sheffield on 24 June 2017. There were a range of activities, exhibits and demonstrations demonstrating how the latest medical research at the University of Sheffield is improving people’s lives. Activities included:
This free public engagement event was held in the Winter Gardens, Sheffield on 24 June 2017. There were a range of activities, exhibits and demonstrations demonstrating how the latest medical research at the University of Sheffield is improving people’s lives. Activities included:
- what growth hormone is, what it does and how we have developed a treatment for growth hormone excess
- how our lungs work, the differences between healthy and asthmatic lungs and why bacteria and viruses can trigger asthma attacks - with a chance to make your own 'snot'
- why bacteria sticks easily to the surface of the eye when it has been damaged and how we have developing new treatments to help stop blindness
- the differences between healthy and diseased motor neurons
- how mathematical models can help lead to better healthcare.
Florey / SHAMROK seminar series: 22 June 17
On Thursday 22 June 2017, Dr Yoojin Oh (Keysight Technologies, Linz, Austria) gave a talk entitled 'Characterization of bacterial surfaces by scanning probe microscopy'.
Abstract: The bacterial cell wall plays a significant role in maintaining cellular structure and resisting turgor pressure. It changes during growth and division and also opens a pathway to transfer information from the outer environment into the cell, suggesting that the cell wall is dynamic and its mechanical properties are of significant importance. Biological scanning probe microscopy (Bio-SPM) is the tool of choice for detailed microbial studies because it allows for studying living microbial organisms in their natural environment at the nano-scale. As the microbial outer membrane interacts with the extra-cellular environment or other surface directly, characterizing its membrane structures and binding capacities provides crucial information for understanding fundamental processes such as bacterial adhesion, surface recognition, and initial attachment to abiotic or biotic surfaces. Bio-SPM is also capable of measuring the cell wall stiffness. Analyses of AFM force-indentation curves yield physical properties of the cellular surface such as Young’s modulus, internal turgor pressure, and the stretching modulus of the bacteria.
Moreover, using a nanomechanical force-sensing approach, we obtained real-time information about the distribution of molecular bonds involved in the adhesion of curliated bacteria to fibronectin. We found that a dense collective network of bonds is formed between curli and fibronectin fibers which results in tight bacterial binding to cell surfaces. Nanomechanical force recognition measurements revealed that approximately 10 bonds were disrupted either sequentially or simultaneously. Thus, amyloid formation of E. coli surfaces leads to multi-bond structural components of fibrous nature that explains the strong mechanical binding of curliated bacteria to hosts and unveils the functions of these proteins in bacterial internalization and invasion. Overall we demonstrate the potential of single-molecule and single-cell force spectroscopy for revealing accurate dynamic and statistical information about the nanomechanical behavior of multiple bonds involved in collective network formation during cellular adhesion.
On Thursday 22 June 2017, Dr Yoojin Oh (Keysight Technologies, Linz, Austria) gave a talk entitled 'Characterization of bacterial surfaces by scanning probe microscopy'.
Abstract: The bacterial cell wall plays a significant role in maintaining cellular structure and resisting turgor pressure. It changes during growth and division and also opens a pathway to transfer information from the outer environment into the cell, suggesting that the cell wall is dynamic and its mechanical properties are of significant importance. Biological scanning probe microscopy (Bio-SPM) is the tool of choice for detailed microbial studies because it allows for studying living microbial organisms in their natural environment at the nano-scale. As the microbial outer membrane interacts with the extra-cellular environment or other surface directly, characterizing its membrane structures and binding capacities provides crucial information for understanding fundamental processes such as bacterial adhesion, surface recognition, and initial attachment to abiotic or biotic surfaces. Bio-SPM is also capable of measuring the cell wall stiffness. Analyses of AFM force-indentation curves yield physical properties of the cellular surface such as Young’s modulus, internal turgor pressure, and the stretching modulus of the bacteria.
Moreover, using a nanomechanical force-sensing approach, we obtained real-time information about the distribution of molecular bonds involved in the adhesion of curliated bacteria to fibronectin. We found that a dense collective network of bonds is formed between curli and fibronectin fibers which results in tight bacterial binding to cell surfaces. Nanomechanical force recognition measurements revealed that approximately 10 bonds were disrupted either sequentially or simultaneously. Thus, amyloid formation of E. coli surfaces leads to multi-bond structural components of fibrous nature that explains the strong mechanical binding of curliated bacteria to hosts and unveils the functions of these proteins in bacterial internalization and invasion. Overall we demonstrate the potential of single-molecule and single-cell force spectroscopy for revealing accurate dynamic and statistical information about the nanomechanical behavior of multiple bonds involved in collective network formation during cellular adhesion.
Florey / SHAMROK seminar series: 02 June 17
On Friday 02 June 17, Dr Amy Bottomley, University of Technology Sydney gave a talk entitled 'We are what we eat: coordinating bacterial cell division with metabolism'.
On Friday 02 June 17, Dr Amy Bottomley, University of Technology Sydney gave a talk entitled 'We are what we eat: coordinating bacterial cell division with metabolism'.
Florey / SHAMROK seminar series: 12 May 17
On 12 May 17, Prof Aidong Han ( Xiamen University) gave a talk entitled 'Cellular signaling through two-component systems in response to extracellular stimuli in bacteria' at a microbiology workshop organised by Prof Simon Foster. This was followed by a talk by Prof Kenneth Bayles (University of Nebraska Medical Center) entitled 'Staphylococcus aureus: a complex developmental organism'.
On 12 May 17, Prof Aidong Han ( Xiamen University) gave a talk entitled 'Cellular signaling through two-component systems in response to extracellular stimuli in bacteria' at a microbiology workshop organised by Prof Simon Foster. This was followed by a talk by Prof Kenneth Bayles (University of Nebraska Medical Center) entitled 'Staphylococcus aureus: a complex developmental organism'.
From Front Line to Cutting Edge & Back Again...
A half day workshop on 25 April 2017, at Northern General Hospital, to help researchers at the University of Sheffield forge new links with clinical staff at Sheffield Teaching Hospitals from an AMR clinical and scientific perspective (and vice versa). This EPSRC sponsored workshop included opportunities to hear about the current clinical problems faced by the NHS. There was also an opportunity for researchers to give a rapid 'flash' presentation on their research as well as lots of opportunities for networking.
A half day workshop on 25 April 2017, at Northern General Hospital, to help researchers at the University of Sheffield forge new links with clinical staff at Sheffield Teaching Hospitals from an AMR clinical and scientific perspective (and vice versa). This EPSRC sponsored workshop included opportunities to hear about the current clinical problems faced by the NHS. There was also an opportunity for researchers to give a rapid 'flash' presentation on their research as well as lots of opportunities for networking.
24 Hour Inspire
A fun, fast, fundraising lecture marathon from 5pm Thursday 30th March to 5pm the following day (in LT01, Hicks Building). Now in its fifth year, this annual event is a celebration of knowledge and learning in memory of two remarkable lecturers and researchers, Dr Tim Richardson and Dr Victoria Henshaw, both of whom our University community sadly lost to cancer. Hosted by the charity Inspiration for Life, all funds from the event will support the Teenage Cancer Trust and Weston Park Hospital Cancer Charity.
There was a fantastic line-up of speakers from across our University. Highlights from Florey and Imagine included:
9pm: Dr Paul Collini - Tuberculosis in the 21st century: the return of consumption?
11pm: Dr Bob Turner and Dr Nic Mullin – Life under the microscope
3.30am: Laia Pasquina Lemonche - The invisible but crucial role of physicists in radiotherapy for cancer
A fun, fast, fundraising lecture marathon from 5pm Thursday 30th March to 5pm the following day (in LT01, Hicks Building). Now in its fifth year, this annual event is a celebration of knowledge and learning in memory of two remarkable lecturers and researchers, Dr Tim Richardson and Dr Victoria Henshaw, both of whom our University community sadly lost to cancer. Hosted by the charity Inspiration for Life, all funds from the event will support the Teenage Cancer Trust and Weston Park Hospital Cancer Charity.
There was a fantastic line-up of speakers from across our University. Highlights from Florey and Imagine included:
9pm: Dr Paul Collini - Tuberculosis in the 21st century: the return of consumption?
11pm: Dr Bob Turner and Dr Nic Mullin – Life under the microscope
3.30am: Laia Pasquina Lemonche - The invisible but crucial role of physicists in radiotherapy for cancer
PubhD Sheffield
Date: Wednesday 15th March, 7pm
Venue: Harrisons 1854 Bar, Regent Terrace, S3 7QA
Florey PhD student Laia Pasquina Lemonche gave a talk entitled 'Can we 'TOUCH' the molecules inside a bacteria with a microscope?'. Please see the PubhD Sheffield website for more details.
Date: Wednesday 15th March, 7pm
Venue: Harrisons 1854 Bar, Regent Terrace, S3 7QA
Florey PhD student Laia Pasquina Lemonche gave a talk entitled 'Can we 'TOUCH' the molecules inside a bacteria with a microscope?'. Please see the PubhD Sheffield website for more details.
Florey / SHAMROK seminar series: 07 February 2017
Professor Laura Piddock (Institute of Microbiology and Infection, University of Birmingham, UK) gave a talk entitled Multi drug efflux systems: from basic research to discovering efflux inhibitors.
Abstract: Only a minority of available antibacterial drugs are active against Gram-negative bacteria. This is due to the impermeability of the outer membrane reducing drug entry and the presence of MDR tripartite efflux pumps, which export most drugs and confer intrinsic MDR. Mutations in regulatory genes increase production of efflux pumps such as the AcrAB-TolC RND MDR pump of Enterobacteriaceae and its close homologues in all Gram-negative bacteria. This confers resistance to clinically useful anti-Gram-negative bacterial drugs such as fluoroquinolones and β-lactams. Genetic inactivation of any one of the genes encoding AcrAB-TolC or homologues gives multi-drug hyper-susceptibility, leads to some antibiotic resistance genes failing to confer clinically relevant levels of resistance, and inhibits development of drug-resistance. Several MDR efflux systems not only confer resistance, but also are required for the bacterium to infect its host and/or to form a biofilm. As MDR efflux is an important contributor to both intrinsic and evolved resistance, efflux systems provide an attractive target/s for the discovery of new inhibitors. Compounds that prevent drug export, efflux inhibitors, sensitize bacteria to multiple antibacterial drugs. An understanding of the mode of drug transport and regulation of the production of efflux pumps offers new opportunities for drug discovery.
Imagine:Imaging Life launch symposium
The launch event for Imagine:Imaging Life, another 2022 Futures initiative, was held on 12-13 January 2017 in the Diamond at the University of Sheffield. It was a 2-day symposium dedicated to cutting edge imaging techniques and their biological application, with keynote presentations from Jennifer Lippincott-Schartz (Janelia Research Campus) and Jie Xiao (Johns Hopkins).
The launch event for Imagine:Imaging Life, another 2022 Futures initiative, was held on 12-13 January 2017 in the Diamond at the University of Sheffield. It was a 2-day symposium dedicated to cutting edge imaging techniques and their biological application, with keynote presentations from Jennifer Lippincott-Schartz (Janelia Research Campus) and Jie Xiao (Johns Hopkins).
IICD seminar series: Professor Sarah Rowland-Jones
On Tuesday 29 November 2016, Professor Sarah Rowland-Jones (University of Oxford) gave a seminar entitled 'Learning from unusual patient cohorts about immunity to HIV' in lecture theatre 3 in the Medical School.
Abstract: As the worldwide HIV epidemic enters its fourth decade, there is still no sign of an effective vaccine to prevent HIV infection. A crucial barrier to vaccine development is our lack of understanding of the correlates of protective immunity that would confer protection against infection, since the great majority of HIV-1-infected people would progress to disease and death without anti-retroviral therapy (ART).
Our group has had the opportunity to study several unusual patient cohorts in many parts of the world that could provide clues about effective immune responses against HIV infection. These include residents of a rural Chinese village who became infected with what appears to be an identical strain of HIV-1 through a contaminated illegal plasma donor scheme in the 1990s, children born to HIV-infected mothers in Nairobi who suffered from extremely rapid disease progression, and West Africans infected with the second strain of HIV, HIV-2, in The Gambia and Guinea-Bissau, many of whom show no signs of immunodeficiency or HIV disease. I will present data from these cohorts that suggest that CD8+ cytotoxic T lymphocytes (CTL) play an important role in HIV control that could be harnessed in vaccine strategies.
Abstract: As the worldwide HIV epidemic enters its fourth decade, there is still no sign of an effective vaccine to prevent HIV infection. A crucial barrier to vaccine development is our lack of understanding of the correlates of protective immunity that would confer protection against infection, since the great majority of HIV-1-infected people would progress to disease and death without anti-retroviral therapy (ART).
Our group has had the opportunity to study several unusual patient cohorts in many parts of the world that could provide clues about effective immune responses against HIV infection. These include residents of a rural Chinese village who became infected with what appears to be an identical strain of HIV-1 through a contaminated illegal plasma donor scheme in the 1990s, children born to HIV-infected mothers in Nairobi who suffered from extremely rapid disease progression, and West Africans infected with the second strain of HIV, HIV-2, in The Gambia and Guinea-Bissau, many of whom show no signs of immunodeficiency or HIV disease. I will present data from these cohorts that suggest that CD8+ cytotoxic T lymphocytes (CTL) play an important role in HIV control that could be harnessed in vaccine strategies.
Inaugural Lecture: Professor Steve Renshaw, Sir Arthur Hall Professor of Medicine
On Thursday 24 November 2016, Professor Steve Renshaw gave his inaugural lecture (New approaches to the treatment of inflammatory diseases of ageing: what can we learn from zebrafish models?) in lecture theatre 2 in the Medical School. This was followed by a wine reception in the C Floor Cafe area.
Abstract: Our health service is creaking under the increasing burden of age-related inflammatory diseases. In my own speciality of respiratory medicine, chronic obstructive airways disease fills our respiratory wards while in other specialities, coronary artery disease, stroke and arthritis impact quality and length of life. These diseases share 2 common features - they are diseases of ageing, driven by inflammation. Yet, despite the universal nature of ageing and inflammation, we have little understanding of how inflammation can just come and go as needed in the young and healthy, yet sticks around and causes damage in disease states.
One of the reasons for our limited understanding is the lack of a suitable model in which we can both manipulate inflammation and see the entire process play out in life. My research has focussed on understanding inflammation, and for the last 12 years this has largely been through the use of the zebrafish as an animal model of inflammation and host-pathogen interaction. Zebrafish are both genetically manipulable and transparent, leading to easy visualisation of immune cells during infection and inflammation. This model allows me to test the ability of a range of candidate genes to influence the resolution of inflammation, and additionally to screen for novel genes involved in this process. At the same time, I can see every immune cell during the whole of an inflammatory episode, where necessary imaging intracellular signalling events in real-time. The small size of our model also lends itself to drug screening and this has identified several potential new therapies for immune disease. In this lecture I will set out the clinical problem as I see it, and the approaches we are taking to address it in my laboratory.
Abstract: Our health service is creaking under the increasing burden of age-related inflammatory diseases. In my own speciality of respiratory medicine, chronic obstructive airways disease fills our respiratory wards while in other specialities, coronary artery disease, stroke and arthritis impact quality and length of life. These diseases share 2 common features - they are diseases of ageing, driven by inflammation. Yet, despite the universal nature of ageing and inflammation, we have little understanding of how inflammation can just come and go as needed in the young and healthy, yet sticks around and causes damage in disease states.
One of the reasons for our limited understanding is the lack of a suitable model in which we can both manipulate inflammation and see the entire process play out in life. My research has focussed on understanding inflammation, and for the last 12 years this has largely been through the use of the zebrafish as an animal model of inflammation and host-pathogen interaction. Zebrafish are both genetically manipulable and transparent, leading to easy visualisation of immune cells during infection and inflammation. This model allows me to test the ability of a range of candidate genes to influence the resolution of inflammation, and additionally to screen for novel genes involved in this process. At the same time, I can see every immune cell during the whole of an inflammatory episode, where necessary imaging intracellular signalling events in real-time. The small size of our model also lends itself to drug screening and this has identified several potential new therapies for immune disease. In this lecture I will set out the clinical problem as I see it, and the approaches we are taking to address it in my laboratory.
Friday 18th November was European Antibiotics Awareness Day and to mark the occasion, SHAMROK and the Florey Institute joined forces to hold a Great British Tea Party to raise funds for the charity Antibiotic Research UK.
This workshop held on 02 Nov 16, funded by EPSRC as part of the Sheffield Antimicrobial Resistance Network (SHAMROK) grant, focused on new methods for understanding microorganisms and AMR coming from engineering and the physical sciences (EPS). The workshop included presentations from a number of international experts on the application of new methods to the AMR challenge.
PubhD Sheffield
PubhD Sheffield is a great way for PhD students to practice public speaking and public engagement skills - in the relaxed atmosphere of a pub! In exchange for a pint (or two), three researchers get 10 minutes to explain their research (with only the aid of a white board and marker pen). There's then 20 minutes of friendly Q&A. The talks are designed to be understood by anyone, and provide a great opportunity to learn about research going on in the city, and learn about something you might have never heard of!
In their first event, Florey PhD student Emily Fisk gave a talk about her research and the Florey Institute. Please see the PubhD Sheffield website for more details.
PubhD Sheffield is a great way for PhD students to practice public speaking and public engagement skills - in the relaxed atmosphere of a pub! In exchange for a pint (or two), three researchers get 10 minutes to explain their research (with only the aid of a white board and marker pen). There's then 20 minutes of friendly Q&A. The talks are designed to be understood by anyone, and provide a great opportunity to learn about research going on in the city, and learn about something you might have never heard of!
In their first event, Florey PhD student Emily Fisk gave a talk about her research and the Florey Institute. Please see the PubhD Sheffield website for more details.
Florey seminar series: 19 Oct 16
Dr Rosalind Allen (School of Physics and Astronomy, Edinburgh University) gave a talk entitled 'How does bacterial growth environment affect antibiotic efficacy and the evolution of resistance'?
Abstract: Many experiments on bacterial action and the evolution of resistance are done in standardised lab conditions, yet bacteria in infections experience complex growth conditions, which can vary in time and space. Exposure to nutrients can also vary between different infections. We have investigated how the richness of the nutrient medium affects the efficacy of action of ribosome-targeting antibiotics. We find apparently conflicting results: some ribosome targeting antibiotics work better on rich media while others work better on poor media. These results can be explained by a simple mathematical model. I will also describe theoretical and preliminary experimental work on the effect of spatial gradients of antibiotic on the evolution of resistance.
Dr Rosalind Allen (School of Physics and Astronomy, Edinburgh University) gave a talk entitled 'How does bacterial growth environment affect antibiotic efficacy and the evolution of resistance'?
Abstract: Many experiments on bacterial action and the evolution of resistance are done in standardised lab conditions, yet bacteria in infections experience complex growth conditions, which can vary in time and space. Exposure to nutrients can also vary between different infections. We have investigated how the richness of the nutrient medium affects the efficacy of action of ribosome-targeting antibiotics. We find apparently conflicting results: some ribosome targeting antibiotics work better on rich media while others work better on poor media. These results can be explained by a simple mathematical model. I will also describe theoretical and preliminary experimental work on the effect of spatial gradients of antibiotic on the evolution of resistance.
Florey seminar series: 10 Oct 16
Dr Pete Monk gave the first Florey / SHAMROK seminar of the series on 10 October 2016, with a talk entitled 'Modification of the host cell surface as a strategy to reduce bacterial adhesion'.
Abstract: Controlling bacterial infection by the repeated use of antibiotics invites the development of bacterial resistance and so new approaches for control are urgently required. One such strategy is the prevention of bacterial adhesion. Bacteria are rapidly removed by normal immune mechanisms unless the bacteria can adhere strongly to host tissues; if this initial step in colonisation can be prevented, infection becomes much less likely. We have recently identified a novel adhesion mechanism used by a range of common bacterial pathogens, which involves a type of membrane ‘microdomain’ that is widely expressed on mammalian cells. These microdomains are characterised by an abundance of members of the tetraspanin protein superfamily. We have demonstrated that short peptides derived from tetraspanins can inhibit the adhesion of a clinical strain of Staph. aureus in a tissue engineered model of human skin, resulting in a significant reduction in bacterial load.
Dr Pete Monk gave the first Florey / SHAMROK seminar of the series on 10 October 2016, with a talk entitled 'Modification of the host cell surface as a strategy to reduce bacterial adhesion'.
Abstract: Controlling bacterial infection by the repeated use of antibiotics invites the development of bacterial resistance and so new approaches for control are urgently required. One such strategy is the prevention of bacterial adhesion. Bacteria are rapidly removed by normal immune mechanisms unless the bacteria can adhere strongly to host tissues; if this initial step in colonisation can be prevented, infection becomes much less likely. We have recently identified a novel adhesion mechanism used by a range of common bacterial pathogens, which involves a type of membrane ‘microdomain’ that is widely expressed on mammalian cells. These microdomains are characterised by an abundance of members of the tetraspanin protein superfamily. We have demonstrated that short peptides derived from tetraspanins can inhibit the adhesion of a clinical strain of Staph. aureus in a tissue engineered model of human skin, resulting in a significant reduction in bacterial load.
The British Association for Lung Research (BALR) summer meeting 2016
Colin Bingle and Helen Marriott hosted the BALR summer meeting at The Edge conference venue in Sheffield on 27-29th July 2016. The meeting theme was 'Fight the good fight: Host pathogen interactions in the lung'.
Colin Bingle and Helen Marriott hosted the BALR summer meeting at The Edge conference venue in Sheffield on 27-29th July 2016. The meeting theme was 'Fight the good fight: Host pathogen interactions in the lung'.
Florey PGR symposium
The Florey PhD students hosted their third annual postgraduate symposium on host-pathogen interactions on Friday 24th June 2016. The symposium was held in Firth Hall, Firth Court at the University of Sheffield.
The programme included keynote speakers Dr Suzan Rooijakkers, Dr Neil Stokes and Dr Hasan Yesilkaya. Please see our news page for more details of the event.
The Florey PhD students hosted their third annual postgraduate symposium on host-pathogen interactions on Friday 24th June 2016. The symposium was held in Firth Hall, Firth Court at the University of Sheffield.
The programme included keynote speakers Dr Suzan Rooijakkers, Dr Neil Stokes and Dr Hasan Yesilkaya. Please see our news page for more details of the event.
Krebs Institute Symposium: "Research across the Boundaries"
Date: Tuesday 14th June 2016
Time: From 9.30am
Place: Firth Hall, Firth Court, University of Sheffield
The programme included two external keynote speakers, Professor Conrad Mullineaux (Queen Mary University of London) and Professor Matthew Fisher (Imperial College London) as well as talks from Sheffield scientists based in MBB, APS, BMS and the Medical School.
Date: Tuesday 14th June 2016
Time: From 9.30am
Place: Firth Hall, Firth Court, University of Sheffield
The programme included two external keynote speakers, Professor Conrad Mullineaux (Queen Mary University of London) and Professor Matthew Fisher (Imperial College London) as well as talks from Sheffield scientists based in MBB, APS, BMS and the Medical School.
Life Festival Infectious Pub Quizes (hosted by the Florey PGR students)
Date: Monday 18th April 2016, 8.30pm
Venue: The York, 243-247 Fulwood Road, Sheffield, S10 3BA
Date: Sunday 24th April 2016, 8.15pm
Venue: Porter Cottage, 286 Sharrow Vale Rd, Sheffield S11 8ZL
As part of Life Festival, some of our PhD students took over the weekly pub quiz at The York (Broomhill) and Porter Cottage (Sharrow Vale Road). The questions tested your knowledge of antimicrobial resistance, Sheffield’s infectious history and how much you know about infectious diseases and treatments.
Date: Monday 18th April 2016, 8.30pm
Venue: The York, 243-247 Fulwood Road, Sheffield, S10 3BA
Date: Sunday 24th April 2016, 8.15pm
Venue: Porter Cottage, 286 Sharrow Vale Rd, Sheffield S11 8ZL
As part of Life Festival, some of our PhD students took over the weekly pub quiz at The York (Broomhill) and Porter Cottage (Sharrow Vale Road). The questions tested your knowledge of antimicrobial resistance, Sheffield’s infectious history and how much you know about infectious diseases and treatments.
Life Festival - Tackling Antibiotic Resistance: From Bench to Bedside
On Tuesday 19 April 2016, PhD students from the Florey Institute presented findings from their projects to members of the public to show how lab work can translate into real world treatments.
On Tuesday 19 April 2016, PhD students from the Florey Institute presented findings from their projects to members of the public to show how lab work can translate into real world treatments.
SHAMROK workshop: Antimicrobial Surfaces ‘U can’t touch this’ – how to prevent and treat microbes attaching to surfaces
This workshop on 06 April 16, funded by EPSRC as part of the Sheffield Antimicrobial Resistance Network (SHAMROK) grant, focused on antimicrobial surfaces from both the clinical and scientific perspectives. The workshop included presentations from a wide range of experts in antimicrobial surfaces, including internationally leading scientists, healthcare professionals and industrial scientists working in R&D relevant to AMR. It highlighted some of the existing research within Sheffield as well as giving plenty of opportunities to take part in discussion sessions and networking activities.
This workshop on 06 April 16, funded by EPSRC as part of the Sheffield Antimicrobial Resistance Network (SHAMROK) grant, focused on antimicrobial surfaces from both the clinical and scientific perspectives. The workshop included presentations from a wide range of experts in antimicrobial surfaces, including internationally leading scientists, healthcare professionals and industrial scientists working in R&D relevant to AMR. It highlighted some of the existing research within Sheffield as well as giving plenty of opportunities to take part in discussion sessions and networking activities.
Science Week 2016 keynote public lecture
Professors Simon Foster (Florey Institute) and Dave Hornby (Department of Molecular Biology and Biotechnology, University of Sheffield) gave the Science Week 2016 keynote public lecture 'Man v Microbe. Battle to the death' on Thursday 17 March 2016. The lecture explored the fascinating world of bacteria - how they help us survive and how they can turn nasty!
Professors Simon Foster (Florey Institute) and Dave Hornby (Department of Molecular Biology and Biotechnology, University of Sheffield) gave the Science Week 2016 keynote public lecture 'Man v Microbe. Battle to the death' on Thursday 17 March 2016. The lecture explored the fascinating world of bacteria - how they help us survive and how they can turn nasty!
SHAMROK seminar series inaugural lecture
SHAMROK (the Sheffield AMR network) initiated their seminar series with an inaugural lecture by Professor Sharon Peacock on 16th March 2016 at 5pm in Lecture Theatre 6, The Diamond at the University of Sheffield.
Seminar title: Translating microbial sequencing into diagnostic and public health microbiology: are we nearly there yet?
Background: The latest generation of benchtop DNA sequencing platforms can provide an accurate whole genome sequence for a broad range of bacteria in less than a day. These could be employed in routine practice to more effectively contain and treat the spread of infectious disease, including multidrug resistant pathogens. The talk focused on the opportunities that rapid microbial WGS presents for the investigation of nosocomial outbreaks caused by multidrug resistant bacteria, and the identification of genetic determinants of antimicrobial resistance associated with a stratified medicine approach to patient care. Barriers to implementation were also discussed.
SHAMROK (the Sheffield AMR network) initiated their seminar series with an inaugural lecture by Professor Sharon Peacock on 16th March 2016 at 5pm in Lecture Theatre 6, The Diamond at the University of Sheffield.
Seminar title: Translating microbial sequencing into diagnostic and public health microbiology: are we nearly there yet?
Background: The latest generation of benchtop DNA sequencing platforms can provide an accurate whole genome sequence for a broad range of bacteria in less than a day. These could be employed in routine practice to more effectively contain and treat the spread of infectious disease, including multidrug resistant pathogens. The talk focused on the opportunities that rapid microbial WGS presents for the investigation of nosocomial outbreaks caused by multidrug resistant bacteria, and the identification of genetic determinants of antimicrobial resistance associated with a stratified medicine approach to patient care. Barriers to implementation were also discussed.
Launch symposium for SHAMROK, the Sheffield AMR Network grant
The launch symposium for the Sheffield antimicrobial resistance network (SHAMROK) grant, funded by the EPSRC, was held at The Ridge, University of Sheffield on 20-21 Junauary 2016.
The symposium set the scene for the challenge from the both the clinical and scientific perspectives. The network wishes to embrace engineering and physical sciences expertise to tackle AMR, by starting new collaborations and fostering new applications of methods and technologies. The symposium included presentations from a wide range of experts in AMR, including internationally leading scientists, healthcare professionals and industrial scientists working in R&D relevant to AMR. It highlighted some of the existing activities within Sheffield, and provided plenty of opportunities to network and make new connections.
The launch symposium for the Sheffield antimicrobial resistance network (SHAMROK) grant, funded by the EPSRC, was held at The Ridge, University of Sheffield on 20-21 Junauary 2016.
The symposium set the scene for the challenge from the both the clinical and scientific perspectives. The network wishes to embrace engineering and physical sciences expertise to tackle AMR, by starting new collaborations and fostering new applications of methods and technologies. The symposium included presentations from a wide range of experts in AMR, including internationally leading scientists, healthcare professionals and industrial scientists working in R&D relevant to AMR. It highlighted some of the existing activities within Sheffield, and provided plenty of opportunities to network and make new connections.
KrebsFest
The KrebsFest was a celebration of the scientific research of Sir Hans Krebs, winner of the Nobel Prize for Medicine in 1953 for his pioneering work at the University of Sheffield.
Events included:
The KrebsFest was a celebration of the scientific research of Sir Hans Krebs, winner of the Nobel Prize for Medicine in 1953 for his pioneering work at the University of Sheffield.
Events included:
Mechanobiology club half day workshop: ‘Use of physical methods at the single cell level’
This event (open to researchers at the University of Sheffield) will take place from 10:30-3pm on Tuesday 8th December 2015. The workshop will take place in various locations in the Pam Liversidge Building.
The workshop will include visual/practical demonstrations of technologies and physical methods from experts from different disciplinary backgrounds which could potentially be applied to the mechanobiology field and a series of 2-3 minute 'flash' presentations detailing research interests, project ideas and/or an area of expertise of interest to the mechanobiology community with the aim of generating research ideas / areas for future development.
This event (open to researchers at the University of Sheffield) will take place from 10:30-3pm on Tuesday 8th December 2015. The workshop will take place in various locations in the Pam Liversidge Building.
The workshop will include visual/practical demonstrations of technologies and physical methods from experts from different disciplinary backgrounds which could potentially be applied to the mechanobiology field and a series of 2-3 minute 'flash' presentations detailing research interests, project ideas and/or an area of expertise of interest to the mechanobiology community with the aim of generating research ideas / areas for future development.