The Florey Institute
  • Home
  • News and Events
  • Research
  • The Team
  • Antimicrobial Resistance MSc
  • Contact
Picture
Ruairidh Wilson

Email:                   rawilson1@sheffield.ac.uk
​PhD:                      2017-
Department:   
Molecular Biology and Biotechnology (MBB)
Supervisor(s): Dr Andrew Fenton (MBB)
                                                                    
​Project:   Mechanisms controlling cell wall biosynthesis in Streptococcus pneumoniae

Streptococcus pneumoniae is a significant global pathogen and a leading cause of community acquired pneumonia. In order to cause infection, S. pneumoniae must overcome the plethora of defence mechanisms the innate immune system possesses, including antimicrobial action by lysozyme.
​

Lysozyme targets and causes degradation of the peptidoglycan layer of the bacterial cell wall. High concentrations of this enzyme are found the mucosal lining where colonisation occurs. S. pneumoniaecan tolerate this exposure by modifying the chemical composition of its cell wall. We have used a Tn-seq approach to identify mutants which are hyper sensitive to the action of lysozyme.

This project aims to further our understanding of the cell wall biosynthetic pathway and how S. pneumoniae
 cells modify their cell wall to tolerate lysozyme stress. Of particular interest is the relationship between the penicillin binding proteins (PBPs) and regulators of the stress response to lysozyme exposure.

The Team

Management Team

Microbiology

Immunology

Clinicians

Allied Disciplines

PhD students

MSc students

Former Members
​and Alumni

Picture
Picture
The University of Sheffield 
Western Bank 
Sheffield, South Yorkshire 
S10 2TN 

United Kingdom
The University of Sheffield | Research | Collaborate | Team | Jobs | Cookies policy | Privacy
Powered by Create your own unique website with customizable templates.

BACK TO TOP

© 2015 The University of Sheffield

© DivTag Templates Ltd | All Rights Reserved