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Megan Cavangh

Email:                   mcavanagh1@sheffield.ac.uk
​PhD:                      2018-
Department:   
Oncology & Metabolism
Academic Unit of Reproductive and Developmental Medicine
Supervisor(s): Professor Dilly Anumba
                                 Dr Paul Heath
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Project:  
 How does vaginal microbial community-composition and metabolism influence infection associated preterm birth across three continents?

Preterm birth is a leading cause of neonatal death for under 5’s. Globally, there is a disparity in PTB rates, with low and middle-income countries shouldering the majority of the global burden. Up to 40% of preterm births are associated with Infection. However, exactly what causes infection to induce preterm birth in some but not others remains unclear.
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My project investigates the effect of vaginal microorganisms, representative of mothers from the UK and globally, on the fetal membranes. I am using techniques including Nanopore sequencing of the vaginal microbiome and in vitro infection models.
Biography

In 2017 I graduated from Bangor University with a BSc in Biology. During my degree I completed a research project supervised by Dr Olga Golyshina that focussed on archaeal diversity in extremely acidic environments. Following this, I studied Reproductive Developmental Medicine at The University of Sheffield where I completed a research project supervised by Professor Dilly Anumba investigating the prediction of preterm birth titled “metabolite and cytokine expression by cervicovaginal epithelial cells co-cultured with Lactobacillus crispatus and Ureaplasma urealyticum”. I continued my work on preterm birth for my PhD and joined the PRIME global health team run by Professor Anumba.

During my time with The Florey Institute, I was the communications officer for 2020 and took part in science outreach including a stall at STEM for girls.

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