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Mabel Johana Ortiz de Leo
Antimicrobial Resistance MSc student: 2020-2021

Email: 
MJOrtizdeleo1@sheffield.ac.uk




Background
I am a Mexican MD graduate and finished my training at the University of Veracruz, Mexico. Since I was in medical school I became interested and involved in public health research specifically in sexually transmitted diseases and HIV. After graduating I started working in the healthcare setting in which I realized the abuse of antimicrobials is becoming a major problem not only in my country but worldwide. It is very worrying to see, how patients die because they have bacterial infections that are resistant to all source of antibiotics. Besides, with the current situation with COVID-19, I became interested with the neurological sequels SARS-CoV2 has in the human, that is why I have recently published a paper in the Elsevier Neurology Journal called: Associated posterior reversible encephalopathy syndrome (PRES) to SARS-CoV-2. Case Report.
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I am currently pursuing the MSc in Antimicrobial Resistance because one of my future career goals is to work along with the World Health Organization in the Global Antimicrobial Resistance Surveillance System (GLASS) and help implement and improve this program in undeveloped countries like mine. 
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Research Project
In my project, I am researching a possible new mechanism for antimicrobial resistance by studying the cryptococcus neoformans heteroresistance mechanisms to fluconazole and the role of macrophages by using susceptibility testing methods such as microdilution assays other microbiology techniques.
 
This research will have an impact on the treatment of cryptococcal meningitis and other neglected tropical diseases that are common in immunocompromised patients. I expect to focus my future work on understanding how antimicrobial resistance mechanisms evolve in immunocompromised patients with a specific focus on LMIC’s, in which fungal diseases are most prevalent. 
 
https://thejohnstonlab.sites.sheffield.ac.uk/home



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The University of Sheffield 
Western Bank 
Sheffield, South Yorkshire 
S10 2TN 

United Kingdom
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