The Florey Institute
  • Home
  • News and Events
  • Research
  • The Team
  • Antimicrobial Resistance MSc
  • Contact
Picture
Laia Pasquina Lemonche
Email:                   lpasquinalemonche1@sheffield.ac.uk
​PhD:                      2016-
Department:   
Physics and Astronomy
Supervisor(s): Prof. Jamie Hobbs (Physics and Astronomy)
                                                                    
​Project:  Using and developing atomic force microscopy and other biological physics approaches to understand how antibiotics kill bacteria

Atomic force microscopy (AFM) is a powerful tool that allows us to measure local mechanical properties, enabling us to image living systems at the nanometric scale. I aim to use and develop these capabilities to study how bacteria (e.g. Staphylococcus aureus) make their cell walls, and how this process is inhibited by β-lactam antibiotics (e.g. penicillin). With antimicrobial resistance (AMR) on the rise, research into how antibiotics kill bacteria is essential for the discovery of novel and promising solutions. This project will be carried out in Jamie Hobbs' lab in collaboration with Simon Foster's group.

The long-term objectives of the project are:
  1. 1. Perform AFM high resolution imaging of peptidoglycan structure of living bacteria (S.aureus).
  2. 2. Understand the dynamic process of penicillin activity through nanoscale imaging.
  3. 3. By means of fluorescence labelling and correlative AFM images, identify penicillin molecules and their distribution through the cell wall of living bacteria.

The Team

Management Team

Microbiology

Immunology

Clinicians

Allied Disciplines

PhD students

MSc students

Former Members
​and Alumni

Picture
Picture
The University of Sheffield 
Western Bank 
Sheffield, South Yorkshire 
S10 2TN 

United Kingdom
The University of Sheffield | Research | Collaborate | Team | Jobs | Cookies policy | Privacy
Powered by Create your own unique website with customizable templates.

BACK TO TOP

© 2015 The University of Sheffield

© DivTag Templates Ltd | All Rights Reserved