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Callum Mynett

Email:                   cmynett1@sheffield.ac.uk
​PhD:                      2017-
Department:   
Molecular Biology and Biotechnology (MBB)
Supervisor(s): Dr Rosie Staniforth (MBB)
                                 Dr Claire Turner (MBB)
                                                                    
​Project:  Enhancing the activity of existing antibiotics on persistent Streptococcal infections by targeting amyloid components of biofilm

Streptococcus pyogenes or Group A Streptococcus (GAS) is capable of causing severe and lethal diseases such as necrotising fasciitis and Streptococcal Toxic-Shock Syndrome and globally accounts for over half a million deaths a year. Remarkably in this day and age of antimicrobial resistance GAS remains sensitive to penicillins and cephalosporins yet recurrent infections and treatment failures are common. One theory as to why this recurrence occurs is due to the formation of biofilms by GAS which may help to shield against antimicrobials and aid in host immune evasion. A common component of many bacterial biofilms are functional amyloid proteins, which utilise the inherent biophysical properties of amyloids to reinforce and provide robustness to the biofilm matrix. 

My project aims to characterise surface adhesion factors in GAS as amyloid forming proteins and biofilm components, using an array of structural and biophysical techniques to do so, in the hope that we will be able to further understand the mechanisms by which GAS is able to form and persist in biofilms. This will help to elucidate novel drug targets to prevent biofilm formation and minimise the probability of GAS treatment failure and recurrence.

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